| Childtime of Orchard Park | 3121 Southwestern Boulevard, Orchard Park, NY 14127 | Center |
| ASC / ECC Child Development Center - South Campus | 4041 Southwestern Boulevard, Orchard Park, NY 14127 | Center |
| Brierwood Child Care Center of Orchard Park | 6400 New Taylor Road, Orchard Park, NY 14127 | Center |
| Doodle Bugs! Child Care & Preschool | 215 Redtail Lane, Orchard Park, NY 14127 | Preschool |
| Edukids | 25 South Lincoln Avenue, Orchard Park, NY 14127 | Preschool |
| Kid's Kingdom Child Care & Preschool Center | 5020 Armor Duells Road, Orchard Park, NY 14127 | Preschool |
| Southwestern Day Care Center | 3210 Southwestern Blvd., Orchard Park, NY 14127 | Center |
| Wee Can Preschool & Childcare | 40 Centre, Orchard Park, NY 14127 | Preschool |
| YMCA Buffalo Niagara | 3870 Sheldon Road, Orchard Park, NY 14127 | Center |
| YMCA Buffalo Niagara | 3580 Eggert Road, Orchard Park, NY 14127 | Center |
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| YMCA Buffalo Niagara | 51 S. Davis Street, Orchard Park, NY 14127 | Center |
| YMCA Buffalo Niagara | 5180 Ellicott Road, Orchard Park, NY 14127 | Center |