| Doodlebug's Child Learning Center | 1267 Noel C. Conaway Road, Guyton, GA 31312 | Preschool |
| Guyton Elementary School Preschool | 719 Central Blvd., Guyton, GA 31312 | Preschool |
| Kathy's Day Kare II | 61 Central Boulevard, Guyton, GA 31312 | Center |
| Marlow Elementary School Preschool | 4650 McCall Road, Guyton, GA 31312 | Preschool |
| Sand Hill Elementary School Preschool | 199 Stagecoach Road, Guyton, GA 31312 | Preschool |
| South Effingham Community Church Childcare Center | 289 Harley Road, Guyton, GA 31312 | Center |
| South Effingham Elementary School Preschool | 767 Kolick Helmly Road, Guyton, GA 31312 | Preschool |
| South Effingham High School | 1220 Noel C. Conaway Rd., Guyton, GA 31312 | Preschool |
| YMCA Pryme Tyme Guyton Elementary Preschool | 719 Central Blvd., Guyton, GA 31312 | Center |
| YMCA Pryme Tyme Marlow Elementary Preschool | 5160 Highway 17 South, Guyton, GA 31312 | Center |
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| YMCA Pryme Tyme Sandhill Elementary Preschool | 199 Stagecoach Ave., Guyton, GA 31312 | Center |
| YMCA Pryme Tyme South Effingham Elementary Preschool | 767 Kolic Helmey Road, Guyton, GA 31312 | Center |