| Carruthers Elementary School Preschool | 80 Candy Ln, Murphysboro, IL 62966 | Preschool |
| Gen John A Logan Attendance Center Preschool | 320 Watson Rd, Murphysboro, IL 62966 | Preschool |
| Immanuel Lutheran School Preschool | 1915 Pine St, Murphysboro, IL 62966 | Preschool |
| Montessori School of Southern Illinois | 507 N 9th St, Murphysboro, IL 62966 | Center |
| Murphysboro Child Development Center | 938 Keough Dr, Murphysboro, IL 62966 | Center |
| Murphysboro Christian Academy Preschool | 805 N 16th St, Murphysboro, IL 62966 | Preschool |
| St Andrews School Preschool | 723 Mulberry St, Murphysboro, IL 62966 | Preschool |
| Tri-county Center Preschool | 1725 Shomaker Dr, Murphysboro, IL 62966 | Preschool |