| Esperanza B. Garza Head Start Child Development | 131 West Garfield, Port Isabel, TX 78578 | Preschool |
| Heavenly Angels | 121 Roosevelt St., Port Isabel, TX 78578 | Preschool |
| Kids By The Bay | 119 W. Monroe, Port Isabel, TX 78578 | Preschool |
| Port Isabel Head Start | 216 Hockaday Drive, Port Isabel, TX 78578 | Preschool |
| Rise and Shine Learning Center | 111 B W. Houston St., Port Isabel, TX 78578 | Preschool |