| Christian County Head Start - Pana | Po Box 928, Effingham, IL 62401 | Preschool |
| Clay County Head Start | Po Box 928, Effingham, IL 62401 | Preschool |
| Dieterich Elementary School Preschool | Po Box 187, Dieterich, IL 62424 | Preschool |
| Discovery Garden | 2511 S Veterans Dr, Effingham, IL 62401 | Preschool |
| Effingham Child Development Center | Po Box 1556, Effingham, IL 62401 | Center |
| Effingham County Head Start | Po Box 928, Effingham, IL 62401 | Preschool |
| Effingham County Head Start - Altamont | Po Box 928, Effingham, IL 62401 | Preschool |
| Effingham County Head Start III | Po Box 928, Effingham, IL 62401 | Preschool |
| Montgomery County Head Start | Po Box 928, Effingham, IL 62401 | Preschool |
| Montgomery County Head Start - Litchfield | Po Box 928, Effingham, IL 62401 | Preschool |
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| Moultrie County Head Start | Po Box 928, Effingham, IL 62401 | Preschool |
| Our New Generations Child Care Center | 800 W Temple Ave, Effingham, IL 62401 | Center |
| Raney Street Day Care | 1800 S Raney St Ste 1, Effingham, IL 62401 | Center |
| Sacred Heart School Preschool | 407 S Henrietta St, Effingham, IL 62401 | Preschool |
| Shelby County Head Start | Po Box 928, Effingham, IL 62401 | Preschool |
| Shelby County Head Start - Cowden | Po Box 928, Effingham, IL 62401 | Preschool |
| St. John's Eagle's Nest Preschool | 901 W Jefferson Ave, Effingham, IL 62401 | Preschool |
| Teutopolis Grade School Preschool | 309 E Main St, Teutopolis, IL 62467 | Preschool |
| Treehouse Day Care and Preschool | 2309 Hoffman Dr, Effingham, IL 62401 | Preschool |
| West Side Pre-School | 900 W Edgar Ave, Effingham, IL 62401 | Preschool |